December 22, 2025
Dear Bill,
I hope that you and Mrs. Rita are in complete health. I am doing well too and keeping busy with my daily work.
First of all, I would like to congratulate you and all your loved ones on the arrival of Christmas and the New Year, and I ask God Almighty to grant you a very joyful and blessed year ahead.
As I mentioned previously, we have carried out fully fundamental (basic, root-level) research on five substances: opium, amphetamine, fentanyl, alcohol, and heroin. Fortunately, the experiments on laboratory rats have been completed as follows: 72 rats for opium, 72 rats for amphetamine, and 72 rats for fentanyl. The papers on opium and amphetamine have been accepted for publication in scientific journals and we are now awaiting their publication. The fentanyl paper has also been submitted to a journal. The reviewers requested revisions twice, which we addressed, and we hope this article will be accepted soon as well.
We are currently preparing the preliminary steps for the heroin experiment on 72 laboratory rats, and we have already obtained approval from the ethics committee.
Regarding the study of alcohol and the experiment on 72 rats, we encountered a problem before implementation. The concern raised was that a large number of rats would die during the alcohol induction process. After reviewing the issue, I realized that the protocol used for inducing alcohol dependence in rats was completely incorrect and flawed. They were administering a very high dose of alcohol all at once, and most rats could not tolerate it. This caused liver failure and led to their death. As we had previously discussed in correspondence, this was a serious methodological issue.
For this reason, I asked Dr. Arvin to first prepare and submit a paper before conducting the animal experiments, titled something along the lines of “A Method or Protocol for Inducing Alcohol Dependence in Rats Using the DST Method.” The reason is that, in the DST method, alcohol is administered starting from a very low dose and gradually increased, allowing dependence symptoms to emerge over a defined period of time. I am confident that using this method will prevent the death of many rats in research laboratories.
My dear friend,
As I have mentioned before, in the global scientific community, specialists and researchers in the field of addiction not only do not consider addiction to be definitively curable, but they also do not truly know how to induce addiction even in rats—because they fail to consider the concepts of adaptation and tolerance.
My goal, as stated previously, is to identify the points of damage in the body—at the physiological, cellular, and molecular levels—caused by the use of drugs and alcohol. Additionally, we aim to identify their common points as well as their differing effects on genes, by examining approximately 20,000 genes and their expression in addicted individuals, and then examining the same ~20,000 genes after treatment.
Through this approach, and by collecting and synthesizing all the data and information, we can study all existing addiction treatment methods. Any group, specialist, scientist, or research center that claims a theory about addiction—we will place it on the scale we have already built and presented (in the form of validated scientific articles), and we will determine its weight and value. If there is the sound of cannon fire and machine guns, we will not be able to hear the sound of a symphony orchestra performing, nor will we understand whether all the instruments are playing correctly or incorrectly.
What I mean is that, from a medical or physiological perspective, we must have a scale—a benchmark—by which we can weigh and evaluate any method or approach. This principle also applies to other diseases, and we are building such benchmarks for them through various studies as well. Although this may be difficult to believe, I am confident that, with your help, I will lay the foundation stone of this great structure.
At present, however, we are facing another challenge: any paper submitted to journals from my country must undergo extensive verification, which takes a great deal of time. Fortunately, because I am somewhat known within the scientific journal community, they are less strict with me. Even so, the papers on the treatment of amphetamine and opium have been accepted for several months but have not yet been published. Likewise, the paper on the human sample—comparing NA and other treatment methods with the DST treatment in Congress 60, based on whole-genome analysis and gene expression—has been accepted after review and verification, but it too has not yet been published. I hope that in the new year, and particularly in January, several of our papers will finally be published.
From the beginning of spring this year until just a few days ago, rainfall in our country was almost zero, and we experienced nearly nine months without rain. Thankfully, in recent days, very good snow and rain have fallen, bringing joy to everyone.
In closing, I take this rainfall—which is a mercy from God—as a good omen, and I wish you a year full of blessings. I am deeply grateful to God for gifting me a friend and brother like you. I am always happy to collaborate with you. On the path of scientific research and the advancement of the humanitarian goals of Congress 60, you have always been my supporter and companion.
I am always proud of my friendship with you.
Joyful be, with ever-increasing love.
Your friend and eternal brother on earth and in heaven,
Hossein